Monday, June 18, 2012

Live, from Stockholm, it's ISOT XVI!

I will be presenting a poster on Sunday, June 24th at ISOT (#167), which I have uploaded the poster to figshare. The first half of the poster should be old hat for avid blog followers, but there's super-sekrit, new data in the last column. If you have any comments about the poster, my research, or the blog, please stop by to chat.

Abstract for the poster:
Mitral cells in the olfactory bulb of mammals encode odors dynamically via short, phasic responses throughout the breathing cycle. Less attention has been paid to how dynamic these responses are between breaths.
To look at the inter-breath dynamics of odor coding, we performed multielectrode recording from the olfactory bulb of awake (and anesthetized) head-restrained mice. We found that the odor code is not stationary, and that individual cells change their response between breaths. On the population level, we show that the first breath is different from each subsequent breath.
We also looked at how odors are coded after the end of odor presentation. We found that individual cells have post-odor responses that can last for seconds. On the population level, this information contains odor- and concentration-specific information. Increasing the length of odor presentation caused longer post-odor responses. To investigate the possibility of network reverberations, we artificially stimulated the olfactory bulb of Thy1-ChR2 mice, and found that stimulation could cause persistent activity for seconds following stimulation. Finally, to show that feedback can come from higher areas, we measured the LFP in the OB of mice with the ipsilateral OB blocked, and found there was still activity.

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