I simply looked at the two most recent issues of both Neuron* and Nature Neuroscience, and counted up the number of main and supplemental figures for each paper (tables were counted as figures; this ignores figure size):
|Number of main (x-axis) and supplemental figures (y-axis) for articles in recent issues of Neuron (black crosses) and Nature Neuroscience (blue dots). Dashed line is for main figs == supplemental figs.|
What can you conclude from this? Depending on your opinion of each journal's editorial rigor, and the Elsevier boycott, you should probably submit your first manuscript to Neuron.
* While compiling these numbers, I saw the Mooney lab has a new paper. Goddamn his lab has been crushing it lately. They labeled specific cell populations using viruses (in the zebra finch), and showed that following deafening, only the striatothalamic (HVCX) projecting neurons underwent synaptic remodeling. In contrast, the motor-projecting neurons (HVC-RA), were stable. The striatothalamic pathway has long been hypothesized to be responsible for plasticity in the system, and this is the best evidence to date.