tag:blogger.com,1999:blog-2878020709809350448.post8009965372255429831..comments2017-11-30T09:35:30.794-05:00Comments on ...And You Will Know Me By The Trail of Papers: Trail Tales: Jose Esteban, and PI3K signaling in synaptic plasticityMikehttp://www.blogger.com/profile/13460212509225238067noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-2878020709809350448.post-47499036268475999272012-06-06T10:48:34.584-04:002012-06-06T10:48:34.584-04:00I think they did look at PTEN and Alzheimer's,...I think they did look at PTEN and Alzheimer's, but I skipped it in the interest of space (and iffy notes). If I remember correctly, they measured the synaptic current, and found that PTEN inhibition rescued NMDAR currents, and actually caused an increase in AMPAR currents over control.Mikehttps://www.blogger.com/profile/13460212509225238067noreply@blogger.comtag:blogger.com,1999:blog-2878020709809350448.post-48125514952580587972012-06-06T10:04:20.635-04:002012-06-06T10:04:20.635-04:00Nice write up!
In the experiments where PTEN inhi...Nice write up! <br />In the experiments where PTEN inhibitor ameliorates Alzheimers symptoms, he could have maybe looked at the AMPAR expression on the synapse to see if the PTEN inhibition is having a specific effect on synaptic plasticity.Vinoy Vijayanhttps://www.blogger.com/profile/08874837734770495078noreply@blogger.com